abstract：...

authors： Chan SW,Tomlinson B,Chan P,Lam CWK

更新日期：2021-12-01 00:00:00

abstract：:Microwave-assisted phospha-Michael addition reactions were carried out in the 13α-oestrone series. The exocyclic 16-methylene-17-ketones as α,β-unsaturated ketones were reacted with secondary phosphine oxides as nucleophilic partners. The addition reactions furnished the two tertiary phosphine oxide diastereomers in h...

authors： Mernyák E,Bartha S,Kóczán L,Jójárt R,Resch V,Paragi G,Vágvölgyi M,Hunyadi A,Bruszel B,Zupkó I,Minorics R

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVE:To investigate the long-term outcomes of coronary artery bypass grafting surgery (CABG) in patients with rheumatoid arthritis (RA). METHODS:Patients with RA (n = 378) were retrospectively compared to patients without RA (n = 7560), all treated with CABG in a multicentre, population-based cohort register stud...

authors： Malmberg M,Palomäki A,Sipilä JOT,Rautava P,Gunn J,Kytö V

更新日期：2021-12-01 00:00:00

abstract：:Selenium levels in the Inuit population of Greenland have been declining during the last decades. The association between Selenium and asthma has been investigated previously, but with conflicting results. The objective was to measure human serum Se (s-Se) in Greenlandic seafood processing workers, to compare with lev...

authors： Laustsen BH,Omland Ø,Würtz ET,Jørgensen L,Bønløkke JH

更新日期：2021-12-01 00:00:00

abstract：:The nucleus, central to cellular activity, relies on both direct mechanical input as well as its molecular transducers to sense external stimuli and respond by regulating intra-nuclear chromatin organization that determines cell function and fate. In mesenchymal stem cells of musculoskeletal tissues, changes in nuclea...

authors： Goelzer M,Goelzer J,Ferguson ML,Neu CP,Uzer G

更新日期：2021-12-01 00:00:00

abstract：:The first secretion, 24-h post parturition of the mammary glands of sows, known as colostrum, is high in protein and low in lactose and fat. As a consequence of an insufficient ingestion of colostrum, more than 50% of piglets fail to reach weaning and die. The composition and some functions of colostrum have been prev...

authors： Inoue R,Tsukahara T

更新日期：2021-12-01 00:00:00

abstract：:Estradiol regulates thyroid function, and chloride channels are involved in the regulation of thyroid function. However, little is known about the role of chloride channels in the regulation of thyroid functions by estrogen. In this study, the effects of estrogen on chloride channel activities in human thyroid Nthy-or...

authors： Yu M,Wei Y,Zheng Y,Yang L,Meng L,Lin J,Xu P,Mahdy SANA,Zhu L,Peng S,Chen L,Wang L

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:Considering the advances in functional rehabilitation in recent decades, therapist-oriented home rehabilitation (TOHR) has been increasingly used in the field of physical therapy because it increases patient compliance and reduces health system costs. The objective of this study was to investigate the effect...

authors： Almeida CHS,Reis LFDF,Nascimento LPADS,Soares AR,Maioli MCP,Lopes AJ

更新日期：2021-12-01 00:00:00

abstract：:This study aimed to evaluate technological (acidification, proteolysis, lipolysis, resistance to low pH, NaCl, and bile salts) and biopreservation (antimicrobial activity against foodborne pathogens) features of 1002 LAB by high throughput screening (HTS) methods. The LAB was isolated from 11 types of Brazilian artisa...

authors： Margalho LP,Kamimura BA,Brexó RP,Alvarenga VO,Cebeci AS,Janssen PWM,Dijkstra A,Starrenburg MJC,Sheombarsing RS,Cruz AG,Alkema W,Bachmann H,Sant'Ana AS

更新日期：2021-12-01 00:00:00

abstract：:Heart failure with preserved ejection fraction (HFpEF) might soon become the most prevalent type of acute heart failure. Still, despite more than 30 years of research on HFpEF, not only do we lack specific treatment, but also a generally accepted definition of HFpEF. Since 2016, several definitions and algorithms have...

authors： Kapłon-Cieślicka A,Lund LH

更新日期：2021-12-01 00:00:00

abstract：:Cancer immunotherapy approaches that utilize or enhance patients' inherent immunity have received extensive attention in the past decade. Biomaterial-based nanocarriers with tunable physicochemical properties offer significant promise in cancer immunotherapies. They can lower payload toxicity, provide sustained releas...

authors： Liu L,Wannemuehler MJ,Narasimhan B

更新日期：2021-12-01 00:00:00

abstract：:Vibrio parahaemolyticus has caused widespread mortality in Indian shrimp aquaculture in recent years. However, there are insufficient genome data for the isolates from Indian shrimp vibriosis to analyze genetic diversity and track the acquisition of genetic features that could be involved in virulence and fitness. In ...

authors： Prithvisagar KS,Krishna Kumar B,Kodama T,Rai P,Iida T,Karunasagar I,Karunasagar I

更新日期：2021-12-01 00:00:00

abstract：PURPOSE:To evaluate the impact the COVID-19-related national lockdown has had on Ophthalmologic Outpatient Care in an Italian Tertiary Medical Centre. METHODS:We reviewed all the performances that were carried out as outpatient services at our department between 1 January 2020 and 30 November 2020. We compared data am...

authors： Savastano A,Ripa M,Savastano MC,Kilian R,Marchini G,Rizzo S

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:Compared with the 3 + 7 regimen, the cladribine-containing regimen has led to improvements in the rate of complete remission (CR) in the treatment of newly diagnosed acute myeloid leukemia (AML) patients. We conducted a systematic review and meta-analysis to investigate the overall efficacy and safety of cla...

authors： Pan Q,Li J

更新日期：2021-12-01 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been proposed as potential targets in OSCC gene therapy. Thus, the study aims to analyze how they exert functions in OSCC. LINC00958, AIM2, Gasdermin D (GSDMD) and tumor protein p53 (TP53) expression levels are analyzed by Quantitative Real-time PCR (qPCR) or Western blotting (WB) i...

authors： Jiang L,Ge W,Cui Y,Wang X

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Testosterone is associated with sexual desire and performance in men, but little is known about cognitive mechanisms underlying this relationship. Even less is known about the influence of estradiol, despite its production from testosterone, and high receptor density in brain regions related to male sexual b...

authors： Palmer-Hague JL,Wong STS,Wassersug RJ,Kingstone A,Wibowo E

更新日期：2021-12-01 00:00:00

abstract：...

authors： Lei X,Liu Q,Li S,Zhang Z,Yang X

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Microscopic colitides are chronic immune-inflammatory bowel diseases. The typical presentation is chronic, watery diarrhoea. Inflammation mostly cannot be visualized via macroscopic inspection. The diagnosis thus requires histologic sampling. The clinical picture can vary. New investigations can prove valuab...

authors： Fedor I,Zold E,Barta Z

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Leptin in breast milk play a significant role in metabolic programming. OBJECTIVE:The aim of this study to evaluate the relationship between leptin levels in maternal serum and breast milk, and certain anthropometric measurements of infants and mothers. METHODS:This study was conducted with 65 females and ...

authors： Çağiran Yilmaz F,Özçelik AÖ

更新日期：2021-12-01 00:00:00

abstract：:In recent years, the incidence and mortality of myocardial infarction (MI) have been increasing throughout the world, threatening public health. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), play critical roles in the progression of MI. The present study aimed to investigat...

authors： Nie S,Cui X,Guo J,Ma X,Zhi H,Li S,Li Y

更新日期：2021-12-01 00:00:00

abstract：:An accumulating number of studies have found that long noncoding RNAs (lncRNAs) participate in breast cancer (BC) development. LncRNA VCAN-AS1, a novel lncRNA, has been confirmed to regulate the progression of gastric cancer, while its role in BC is elusive. Here, our results illustrate that VCAN-AS1 is overexpressed ...

authors： Du P,Luo K,Li G,Zhu J,Xiao Q,Li Y,Zhang X

更新日期：2021-12-01 00:00:00

abstract：:A series of [1]benzothieno[2,3-c]pyridines was synthesised. Most compounds were chosen by NCI-USA to evaluate their anticancer activity. Compounds 5a-c showed prominent growth inhibition against most cell lines. 5c was selected at five dose concentration levels. It exhibited potent broad-spectrum anticancer activity w...

authors： Khalil NA,Ahmed EM,Zaher AF,Sobh EA,El-Sebaey SA,El-Zoghbi MS

更新日期：2021-12-01 00:00:00

abstract：:Diabetic nephropathy (DN) is a complication of diabetes that induces the development of end-stage renal disease (ESRD). The pathogenesis of DN is reported to be closely related to the activation of the NOD-like receptor 3 (NLRP3) inflammasome in renal glomerular endothelial cells. Omarigliptin is a novel dipeptidyl pe...

authors： Li L,Qian K,Sun Y,Zhao Y,Zhou Y,Xue Y,Hong X

更新日期：2021-12-01 00:00:00

abstract：:Allogeneic kidney transplantation (renal allograft) is the most effective treatment for advanced kidney disease. Previous studies have indicated that ferroptosis participates in the progression of acute kidney injury and renal transplant failure. However, few studies have evaluated the prognostic value of ferroptosis ...

authors： Fan Z,Liu T,Huang H,Lin J,Zeng Z

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Extracorporeal membrane oxygenation (ECMO) provides circulatory support in children with congenital heart disease, particularly in the setting of cardiopulmonary failure and inability to wean from cardiopulmonary bypass. This study summarized the clinical application of ECMO in the treatment of heart failure...

authors： Yu X,Yang Y,Zhang W,Guo Z,Shen J,Xu Z,Zhang H,Wang W

更新日期：2021-12-01 00:00:00

abstract：:Geldanamycin (GDM) has been modified by different type neutral/acidic/basic substituents (1-7) and by quinuclidine motif (8), transformed into ammonium salts (9-13) at C(17). These compounds have been characterised by spectroscopic and x-ray methods. Derivative 8 shows better potency than GDM in MCF-7, MDA-MB-231, A54...

authors： Skrzypczak N,Pyta K,Ruszkowski P,Mikołajczak P,Kucińska M,Murias M,Gdaniec M,Bartl F,Przybylski P

更新日期：2021-12-01 00:00:00

abstract：PURPOSE:This controlled study assessed whether there was a correlation between serum total testosterone levels and bladder cancer (BCa) in terms of tumor grade and stage as objective measures in adult men. MATERIALS AND METHOD:Our prospectively-designed study included 257 patients who were diagnosed with primary BCa a...

authors： Kafkasli A,Yazici O,Can U,Dinçer E,Akça O,Canguven O

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:The traditional model for subspecialty education in internal medicine (IM) residencies is a short inpatient consult rotation, which often lacks outpatient exposure and continuity with faculty. Our IM residency program developed a longitudinal subspecialty clinic (LSC) experience, which pairs categorical IM r...

authors： Consunji MV,Kohlwes RJ,Babik JM

更新日期：2021-12-01 00:00:00

abstract：:Small molecule-chemotherapeutic drug conjugate nanoparticles (SMCDC NPs) has a great advantage in improving drug loading. However, the factors which influence these conjugates forming stable nanoparticles (NPs) are currently unclear. In our previous studies, we synthesized a series of fatty acid-paclitaxel conjugates ...

authors： Xu MQ,Zhong T,Yao X,Li ZY,Li H,Wang JR,Feng ZH,Zhang X

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:After the 'first wave' in spring 2020, opinions regarding the threat and measures against COVID-19 seemed to vary among German general practitioners (GPs). OBJECTIVES:To systematically investigate opinions and to identify subgroups of GPs sharing similar views. METHODS:A questionnaire was sent to all 210 p...

authors： Linde K,Bergmaier C,Torge M,Barth N,Schneider A,Hapfelmeier A

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:Video consultations are increasingly used to communicate with patients, particularly during the current COVID-19 pandemic. However, training in video consultation skills receives scant attention in the literature. We sought to introduce this important topic to our undergraduate medical school curriculum. OB...

authors： Gunner CK,Eisner E,Watson AJ,Duncan JL

更新日期：2021-12-01 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT) of lens epithelial cells enhanced their proliferation and migration and therefore induced the occurrence of posterior capsule opacity (PCO). Some studies revealed that Krüppel-like factor 1 (KLF1) promoted the proliferation and invasion of multiple types of cancer cells. Bes...

authors： Shi G,Yang F

更新日期：2021-12-01 00:00:00

abstract：:The naturally occurring isothiocyanate sulforaphane, found in vegetables, shows promising anti-inflammatory, anti-apoptosis, and anti-oxidative effects. Whether sulforaphane protects against lipopolysaccharide (LPS)-induced injury in intestinal epithelial cells is unclear. The present study examines the ability of sul...

authors： Zhang YJ,Wu Q

更新日期：2021-12-01 00:00:00

abstract：:Intervertebral disc degeneration (IDD) has been well-recognized as one of the causes of vast lower back pain. The objective of the current study intends to elucidate the influence and regulatory molecular mechanisms of c-Jun on IDD. This study established an IDD model of Sprague-Dawley (SD) rats by needle puncture. An...

authors： Lei M,Zhao K,Hua W,Wang K,Li S,Wu X,Yang C

更新日期：2021-12-01 00:00:00

abstract：:Nanogels have high tunability and stability while being able to sense and respond to external stimuli by showing changes in the gel volume, water content, colloidal stability, mechanical strength, and other physical/chemical properties. In this article, advances in the preparation of nanogels will be reviewed. The app...

authors： Li C,Obireddy SR,Lai WF

更新日期：2021-12-01 00:00:00

abstract：:Raman spectroscopy was applied to an aqueous solution containing D-mannose and D-glucose at a fixed dry matter content. The Raman measurement apparatus was adapted online at the industrial scale to monitor a bioprocess including an epimerization reaction. Online Raman spectroscopy and deconvolution techniques were suc...

authors： Dumouilla V,Dussap CG

更新日期：2021-12-01 00:00:00

abstract：:Sepsis is a systemic inflammatory response caused by infection and is a major cause of neonatal death. This study explored the miR-455-5p in neonatal sepsis, and further investigated the diagnostic and prognostic value of miR-455-5p in neonatal sepsis (NS). The levels of serum miR-455-5p in 88 healthy controls and 90 ...

authors： Mao YY,Su C,Fang CC,Fan XP,Wang LP,Zhu SS,Yao HM

更新日期：2021-12-01 00:00:00

abstract：:Vascular smooth muscle cell senescence plays a pivotal role in the pathogenesis of atherosclerosis. Anagliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor for the treatment of hyperglycemia. Recent progress indicates that DPP-4 inhibitors show a wide range of cardiovascular benefits. We hypothesize that Anagli...

authors： Zhao J,He X,Zuo M,Li X,Sun Z

更新日期：2021-12-01 00:00:00

abstract：:Rectal cancer is a life‑threatening disease worldwide. Chemotherapy resistance is common in rectal adenocarcinoma patients and has unfavorable survival outcomes; however, its related molecular mechanisms remain unknown. To identify genes related to the initiation and progression of rectal adenocarcinoma, three dataset...

authors： Lv QY,Zou HZ,Xu YY,Shao ZY,Wu RQ,Li KJ,Deng X,Gu DN,Jiang HX,Su M,Zou CL

更新日期：2021-12-01 00:00:00

abstract：BACKGROUND:This paper uses a SEIR(D) model to analyse the time-varying transmission dynamics of the COVID-19 epidemic in Korea throughout its multiple stages of development. This multi-stage estimation of the model parameters offers a better model fit compared to the whole period analysis and shows how the COVID-19's i...

authors： Shin HY

更新日期：2021-12-01 00:00:00